CAP1, a target of miR‐144/451, negatively regulates erythroid differentiation and enucleation
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چکیده
منابع مشابه
Ski negatively regulates erythroid differentiation through its interaction with GATA1.
The Ski oncoprotein dramatically affects cell growth, differentiation, and/or survival. Recently, Ski was shown to act in distinct signaling pathways including those involving nuclear receptors, transforming growth factor beta, and tumor suppressors. These divergent roles of Ski are probably dependent on Ski's capacity to bind multiple partners with disparate functions. In particular, Ski alter...
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ZFP36L1 is a member of a family of CCCH tandem zinc finger proteins (TTP family) able to bind to AU-rich elements in the 3'-untranslated region of mRNAs, thereby triggering their degradation. The present study suggests that such mechanism is used during hematopoiesis to regulate differentiation by posttranscriptionally modulating the expression of specific target genes. In particular, it demons...
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BACKGROUND Human globin gene expression is precisely regulated by a complicated network of transcription factors and chromatin modifying activities during development and erythropoiesis. Eos (Ikaros family zinc finger 4, IKZF4), a member of the zinc finger transcription factor Ikaros family, plays a pivotal role as a repressor of gene expression. The aim of this study was to examine the role of...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2021
ISSN: 1582-1838,1582-4934
DOI: 10.1111/jcmm.16067